Fig. 4. The 16 commonly altered miRNAs in primary tumour and lymph node metastasis regulate the expression of genes involved in immune response, cellular proliferation, and extracellular matrix remodelling, related to invasion and metastatic potential. A subset of 12 miRNAs was further downregulated in metastasis, suggesting a potential role for deregulated miRNA-mRNA networks in disease progression. This figure was generated using BioRender.com.